Johnson & Johnson’s COVID-19 vaccine differs significantly from Pfizer’s, Moderna’s

Johnson & Johnson’s COVID-19 vaccine differs significantly from Pfizer’s, Moderna’s

JnJ’s vaccine seems to be much less inclined than Pfizer-BioNTech’s and Moderna’s, to set off the sorts of unintended effects that require monitoring.

Johnson & Johnson’s COVID-19 vaccine differs considerably from Pfizer’s, Moderna’s

A well being employee prepares a vaccine injection for administration. Picture credit score: UNICEF/Nahom Tesfaye

A 3rd efficient weapon was added to America’s arsenal in opposition to the coronavirus Saturday when the Meals and Drug Administration granted emergency use authorization for a vaccine developed by Johnson & Johnson. The corporate mentioned it might begin delivery thousands and thousands of doses early this week and would offer america with 100 million doses by the tip of June. Along with 600 million doses of the nation’s first two licensed vaccines, made by Pfizer-BioNTech and Moderna, which can be on account of be delivered over the subsequent 4 months, that must be sufficient to cowl each American grownup who desires to be vaccinated.

The brand new vaccine differs markedly from the 2 already in use in america. Right here is how they evaluate.

One shot as a substitute of two

The Johnson & Johnson vaccine is run in a single shot, whereas the Pfizer-BioNTech and Moderna vaccines are given in two photographs a number of weeks aside.

Johnson  Johnsons COVID19 vaccine differs considerably from Pfizers Modernas

Vial of the Johnson & Johnson COVID-19 vaccine. Picture: Johnson & Johnson

How J&J’s COVID-19 shot works

The Johnson & Johnson vaccine makes use of a special technique to prime the physique to struggle off COVID-19 : a viral vector known as Ad26. Viral vectors are frequent viruses which were genetically altered in order that they don’t trigger sickness however can nonetheless trigger the immune system to construct up its defenses. The Pfizer-BioNTech and Moderna vaccines use messenger RNA to do this.

How nicely it really works

The Johnson & Johnson vaccine is rated as extremely efficient at stopping severe sickness and dying, because the Pfizer-BioNTech and Moderna vaccines are. It’s also very efficient at stopping milder sickness, although a bit much less so than these two. It seems to do nicely in opposition to the extremely contagious B.1.351 variant, first recognized in South Africa, that has given at the least one different vaccine candidate hassle.

Storage and dealing with

The Johnson & Johnson vaccine doesn’t need to be saved at extraordinarily low temperatures just like the Pfizer-BioNTech vaccine. It will possibly safely be saved in an atypical fridge for 3 months, for much longer than the Moderna vaccine, which spoils after a month if not saved frozen.

Uncomfortable side effects

The Johnson & Johnson vaccine seems to be much less inclined than the Pfizer-BioNTech and Moderna vaccines to set off the sorts of unintended effects that require monitoring after the injection, which can make it extra appropriate to be used at drive-thru vaccination websites. There have been studies that unintended effects are typically felt extra strongly after second doses, which the Johnson & Johnson vaccine doesn’t require.

Patrick J. Lyons. c.2021 The New York Instances Firm

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